Kevin Can F**k Himself is actually a drama (a rather depressing one). Wikipedia describes it as "The show presents contrasting perspectives of her experience - a typical sitcom wife when Allison is with her husband Kevin, shown with a multiple-camera setup and canned laughter, and as a woman navigating a difficult personal path, filmed in the single-camera setup more common to television dramas." They also desaturate the colors for the drama scenes. In this case it would make no sense to use an audience since that's not even half of the story (the majority are non-sitcom scenes I'd say).